Friedman S M, Tumang J R, Crow M K
Department of Medicine, Cornell University Medical College, Hospital for Special Surgery, New York, New York.
Rheum Dis Clin North Am. 1993 Feb;19(1):207-22.
A recently characterized group of immunologically active microbial products, termed superantigens, may provide the etiopathogenic link between antecedent infection and the subsequent development of autoimmunity in the genetically susceptible host. In this article, the authors review the cellular interactions that underlie autoimmune disease and emphasize the central role played by T lymphocytes. Based on the unique properties of the superantigen and data derived from experimental animal models and clinical studies of human autoimmune disease, a hypothesis that these molecules could trigger both systemic and organ-specific autoimmunity was developed.
最近鉴定出的一类具有免疫活性的微生物产物，称为超抗原，可能为遗传易感宿主先前感染与自身免疫性随后发展之间提供病因学联系。在本文中，作者回顾了自身免疫性疾病背后的细胞相互作用，并强调了T淋巴细胞所起的核心作用。基于超抗原的独特特性以及来自实验动物模型和人类自身免疫性疾病临床研究的数据，提出了一种假说，即这些分子可能引发全身性和器官特异性自身免疫。
