Dahlmann N
Institute of Clinical Biochemistry, University of Bonn, F.R.G.
Anticancer Res. 1991 Jan-Feb;11(1):225-8.
A recently discovered enzyme of the pyrimidine pathway, deoxythymidine-5'-triphosphatase (dTTPase), was estimated in sera from leukemic mice and 64 untreated patients with non-Hodgkin's lymphoma (NHL) as well as 30 patients with plasmocytoma. At the age of 19 weeks the Mov-9 substrain of 129 mice developed leukemia in contrast to the congenic controls. Patient lymph node biopsies were classified according to the Kiel classification. The results showed a significant correlation between dTTPase activity and the onset of proliferation (studied in mice), as well as the grade of malignancy (studied in men). The more advanced the disease or the less aggressive the tumor, the higher the dTTPase activity. This gives rise to the speculation that dTTPase might be part of a control in the proliferation process.
最近在嘧啶途径中发现的一种酶，脱氧胸苷-5'-三磷酸酶（dTTPase），在白血病小鼠血清、64例未经治疗的非霍奇金淋巴瘤（NHL）患者以及30例浆细胞瘤患者中进行了测定。19周龄时，129小鼠的Mov-9亚系与同基因对照相比发生了白血病。患者淋巴结活检根据基尔分类法进行分类。结果显示，dTTPase活性与增殖起始（在小鼠中研究）以及恶性程度（在人类中研究）之间存在显著相关性。疾病越晚期或肿瘤侵袭性越低，dTTPase活性越高。这引发了一种推测，即dTTPase可能是增殖过程中调控的一部分。
