Ko D, Raaphorst G P, Feeley M M, Danjoux C E, Maroun J A, Evans W K
Ottawa Regional Cancer Centre, Ontario, Canada.
Anticancer Res. 1991 Jan-Feb;11(1):235-9.
Two human small cell lung cancer (SCLC) cell lines were used to evaluate the in vitro response to lonidamine and cisplatin exposure. The two cell lines both showed growth inhibition when exposed to lonidamine alone at concentrations greater than 50 micrograms/ml; however, one cell line (H69) was more sensitive. When cisplatin was combined with lonidamine a synergistic interaction was observed when cells were exposed to 10 microM cisplatin for 1 hour combined with lonidamine at concentrations of 50 micrograms/ml or greater. At a concentration of 25 micrograms/ml lonidamine combined exposure with cisplatin had no effect on cell growth or viability.
使用两个人类小细胞肺癌（SCLC）细胞系来评估对氯尼达明和顺铂暴露的体外反应。当单独暴露于浓度大于50微克/毫升的氯尼达明时，这两个细胞系均显示出生长抑制；然而，其中一个细胞系（H69）更敏感。当顺铂与氯尼达明联合使用时，当细胞暴露于10微摩尔/升顺铂1小时并联合使用浓度为50微克/毫升或更高的氯尼达明时，观察到协同相互作用。在氯尼达明浓度为25微克/毫升时，与顺铂联合暴露对细胞生长或活力没有影响。
