Vaidya Dhananjay, Dobs Adrian, Gapstur Susan M, Golden Sherita Hill, Hankinson Arlene, Liu Kiang, Ouyang Pamela
Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Metabolism. 2008 Jun;57(6):782-90. doi: 10.1016/j.metabol.2008.01.019.
The traditional lipid profile differs by sex hormone levels. However, associations of sex hormones with lipoprotein subfractions, which may more accurately represent metabolic pathways to atherosclerosis, are not well studied. We quantified the cross-sectional associations of endogenous sex hormones with lipoprotein subfractions in 3143 men and 2038 postmenopausal women who were not on hormone replacement therapy, aged 45 to 84 years, in the Multi-Ethnic Study of Atherosclerosis baseline examination. Particle sizes and numbers of very low-density (VLDL), low-density (LDL), and high-density (HDL) lipoproteins were measured by nuclear magnetic resonance. In both men and women, after multivariable adjustment, higher sex hormone binding globulin (SHBG) levels are associated with smaller, fewer VLDL; larger, fewer LDL; and larger, more numerous HDL particles, whereas higher endogenous estradiol levels are associated with smaller VLDL and smaller, more numerous HDL and LDL particles (all P < .05). Testosterone (adjusted for SHBG) is associated with smaller VLDL particles in men but not women (sex difference P = .040). Higher dehydroepiandrosterone levels are associated with more numerous, smaller VLDL particles only in women (sex difference P = .030, .004, respectively). In conclusion, we found sex differences in the association of endogenous androgens with lipoprotein particle sizes and numbers. Higher endogenous estradiol, but lower SHBG, is associated with a more atherogenic lipoprotein particle profile. These findings highlight the potential to improve the lipoprotein profile with sex hormones, but emphasize the intricacies of the interactions.
传统的血脂谱因性激素水平而异。然而，性激素与脂蛋白亚组分之间的关联尚未得到充分研究，而脂蛋白亚组分可能更准确地反映动脉粥样硬化的代谢途径。在动脉粥样硬化多民族研究的基线检查中，我们对3143名男性和2038名未接受激素替代疗法、年龄在45至84岁之间的绝经后女性体内内源性性激素与脂蛋白亚组分之间的横断面关联进行了量化。通过核磁共振测量极低密度（VLDL）、低密度（LDL）和高密度（HDL）脂蛋白的颗粒大小和数量。在男性和女性中，经过多变量调整后，较高的性激素结合球蛋白（SHBG）水平与更小、数量更少的VLDL；更大、数量更少的LDL；以及更大、数量更多的HDL颗粒相关，而较高的内源性雌二醇水平与更小的VLDL以及更小、数量更多的HDL和LDL颗粒相关（所有P < 0.05）。睾酮（校正SHBG后）与男性中更小的VLDL颗粒相关，但与女性无关（性别差异P = 0.040）。较高的脱氢表雄酮水平仅与女性中数量更多、更小的VLDL颗粒相关（性别差异分别为P = 0.030、0.004）。总之，我们发现内源性雄激素与脂蛋白颗粒大小和数量之间的关联存在性别差异。较高的内源性雌二醇，但较低的SHBG，与更具动脉粥样硬化性的脂蛋白颗粒谱相关。这些发现凸显了利用性激素改善脂蛋白谱的潜力，但也强调了相互作用的复杂性。
