Adamska K, Bellinghausen R, Voelkel A
Poznań University of Technology, Institute of Chemical Technology and Engineering, pl. M. Sklodowskiej-Curie 2, 60-965 Poznań, Poland.
J Chromatogr A. 2008 Jun 27;1195(1-2):146-9. doi: 10.1016/j.chroma.2008.05.020. Epub 2008 May 14.
The Hansen solubility parameter (HSP) seems to be a useful tool for the thermodynamic characterization of different materials. Unfortunately, estimation of the HSP values can cause some problems. In this work different procedures by using inverse gas chromatography have been presented for calculation of pharmaceutical excipients' solubility parameter. The new procedure proposed, based on the Lindvig et al. methodology, where experimental data of Flory-Huggins interaction parameter are used, can be a reasonable alternative for the estimation of HSP values. The advantage of this method is that the values of Flory-Huggins interaction parameter chi for all test solutes are used for further calculation, thus diverse interactions between test solute and material are taken into consideration.
汉森溶解度参数（HSP）似乎是用于不同材料热力学表征的有用工具。不幸的是，HSP值的估算可能会引发一些问题。在这项工作中，提出了使用反相气相色谱法的不同程序来计算药用辅料的溶解度参数。基于林德维格等人的方法提出的新程序，利用了弗洛里-哈金斯相互作用参数的实验数据，可能是估算HSP值的合理替代方法。该方法的优点是，所有测试溶质的弗洛里-哈金斯相互作用参数χ值都用于进一步计算，从而考虑了测试溶质与材料之间的多种相互作用。
