Adamska Katarzyna, Voelkel Adam
Poznań Technical University, Institute of Chemical Technology and Engineering, Pl. M. Sklodowskiej-Curie 2, 60-965 Poznań, Poland.
Int J Pharm. 2005 Nov 4;304(1-2):11-7. doi: 10.1016/j.ijpharm.2005.03.040. Epub 2005 Sep 23.
The principle aim of this work was an application of inverse gas chromatography (IGC) for the estimation of solubility parameter for pharmaceutical excipients. The retention data of number of test solutes were used to calculate Flory-Huggins interaction parameter (chi1,2infinity) and than solubility parameter (delta2), corrected solubility parameter (deltaT) and its components (deltad, deltap, deltah) by using different procedures. The influence of different values of test solutes solubility parameter (delta1) over calculated values was estimated. The solubility parameter values obtained for all excipients from the slope, from Guillet and co-workers' procedure are higher than that obtained from components according Voelkel and Janas procedure. It was found that solubility parameter's value of the test solutes influences, but not significantly, values of solubility parameter of excipients.
这项工作的主要目的是应用反相气相色谱法（IGC）来估算药用辅料的溶解度参数。使用多种测试溶质的保留数据，通过不同程序计算弗洛里 - 哈金斯相互作用参数（χ1,2∞），进而计算溶解度参数（δ2）、校正溶解度参数（δT）及其组分（δd、δp、δh）。评估了测试溶质溶解度参数（δ1）的不同值对计算值的影响。从斜率、Guillet及其同事的程序获得的所有辅料的溶解度参数值高于根据Voelkel和Janas程序从组分获得的值。结果发现，测试溶质的溶解度参数值对辅料的溶解度参数值有影响，但影响不显著。
