Wagner Denisa D, Frenette Paul S
Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Blood. 2008 Jun 1;111(11):5271-81. doi: 10.1182/blood-2008-01-078204.
Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.
血细胞与血管壁的相互作用早在近170年前就有记录。现代研究进展表明，白细胞和血小板与内皮细胞的相互作用处于复杂、动态的细胞和分子网络的核心位置，一旦失调，可能导致病理性炎症和血栓形成，而这正是西方世界发病和死亡的主要原因。在这篇综述中，我们讲述了血细胞与脉管系统相互作用的历史，讨论了最近的进展，并提出了该领域一些尚未解决的问题。
