Platelet interactions with the vessel wall and prosthetic grafts.

Most physicians are aware of the important role that platelets play in thrombus formation. The mechanisms that regulate platelet function are now understood at the molecular level. The same biologic processes that control platelet participation in the hemostatic process also allow platelets to interact with the vessel wall. This review will describe the interaction of platelets with the vessel wall and prosthetic grafts and the physiologic basis and clinical contribution of platelet inhibition to long-term graft patency.