Hill W G, Salisbury B A, Webb A J
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
J Anim Sci. 2008 Oct;86(10):2508-17. doi: 10.2527/jas.2007-0276. Epub 2008 May 23.
Identification of relatives using SNP markers has many possible applications. One is as a route to tracing a food product such as a cut of meat back to its source of origin by identifying the parents of the animal from which the product was derived. We develop methods for using SNP markers with maximum likelihood, allowing for the possibility of genotyping errors that would cause false exclusions by simpler methods. We use expectations of likelihood ratios to consider how gene frequencies in the parental populations, numbers of loci, and error rates affect accuracy. This is further quantified as the risk, the probability that an incorrect sire is identified from a panel that contains many other putative sires including its relatives, using a breeding structure relevant to pig breeding. This appears to be a straightforward and potentially effective means of product tracing.
使用单核苷酸多态性(SNP)标记识别亲属有许多可能的应用。其中之一是通过识别生产该产品的动物的亲本,追溯肉类等食品的来源。我们开发了使用SNP标记的最大似然法,考虑到基因分型错误的可能性,而简单方法可能会因这些错误导致错误排除。我们利用似然比的期望值来考虑亲本群体中的基因频率、基因座数量和错误率如何影响准确性。这进一步量化为风险,即使用与猪育种相关的育种结构,从包含许多其他推定父本(包括其亲属)的面板中识别出错误父本的概率。这似乎是一种直接且可能有效的产品追溯手段。