Briley Laura D, Phillips Charles M
PGY3- Department of Dermatology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA.
Clin Pediatr (Phila). 2008 Oct;47(8):757-61. doi: 10.1177/0009922808318344. Epub 2008 May 23.
Cutaneous mastocytosis can be divided into 4 different clinical variants--urticaria pigmentosa, solitary mastocytoma, diffuse cutaneous mastocytosis, and telangiectasia macularis eruptiva perstans. Skin findings are often accompanied by symptoms secondary to mast cell release of mediators. These symptoms can be both localized to the skin lesion and systemic because of the release of mediators into the bloodstream. The majority of pediatric cases of cutaneous mastocytosis show a good prognosis with gradual resolution of both symptoms and skin lesions. This article will review each of the 4 clinical presentations focusing on pediatric-onset of disease while reviewing the literature.
皮肤肥大细胞增多症可分为4种不同的临床类型——色素性荨麻疹、孤立性肥大细胞瘤、弥漫性皮肤肥大细胞增多症和持久性斑疹性血管扩张症。皮肤表现常伴有肥大细胞释放介质所致的继发性症状。由于介质释放入血，这些症状可局限于皮肤损害部位，也可出现全身性症状。大多数儿童皮肤肥大细胞增多症病例预后良好，症状和皮肤损害会逐渐消退。本文将在回顾文献的同时，重点针对儿童发病情况对这4种临床表现逐一进行综述。
