Otero A, Bustelo X R, Gómez-Márquez J
Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Santiago de Compostela, Galicia, Spain.
Biochim Biophys Acta. 1991 Apr 17;1092(2):184-7. doi: 10.1016/0167-4889(91)90155-q.
We studied here the variations in the mRNA levels of the mitochondrially-encoded subunit II of cytochrome c oxidase (COII) during the proliferation of thymocytes, splenic T-cells and hepatocytes. The COII mRNA levels increased during thymocyte proliferation and decreased when they were growth arrested. However, its levels remained nearly constant during splenic T-cell proliferation and liver regeneration after partial hepatectomy. The different pattern of COII gene expression in the cellular systems analyzed suggests that an increment in the oxidative metabolism could not always be necessary during cell proliferation.
我们在此研究了细胞色素c氧化酶（COII）线粒体编码亚基II的mRNA水平在胸腺细胞、脾T细胞和肝细胞增殖过程中的变化。COII mRNA水平在胸腺细胞增殖期间升高，在生长停滞时降低。然而，在脾T细胞增殖和部分肝切除后的肝再生过程中，其水平几乎保持恒定。在所分析的细胞系统中COII基因表达的不同模式表明，在细胞增殖过程中氧化代谢的增加并非总是必要的。
