Brucker-Davis Françoise, Wagner-Mahler Kathy, Delattre Isabelle, Ducot Béatrice, Ferrari Patricia, Bongain André, Kurzenne Jean-Yves, Mas Jean-Christophe, Fénichel Patrick
Endocrinology Department, Hôpital l'Archet 1, CHU Nice, 151 route de Saint-Antoine, 06200 Nice, France.
Hum Reprod. 2008 Aug;23(8):1708-18. doi: 10.1093/humrep/den186. Epub 2008 May 24.
Since fetal exposure to anti-androgenic and/or estrogenic compounds has adverse effect on animal reproduction, such exposure could be harmful to human fetus. Data are scarce on cryptorchidism and human exposure to endocrine disruptors.
We performed a prospective case-control study to assess the incidence of cryptorchidism and fetal exposure to selected chemicals in the Nice area. One hundred and fifty-one cord bloods (67 cryptorchid, 84 tightly matched controls) and 125 colostrums (56 for cryptorchid and 69 for controls) were screened for xenobiotics, including anti-androgenic dichloro-diphenyl-trichloro-ethylene (DDE), polychlorinated biphenyls (PCBs), and dibutylphthalate (and metabolite monobutylphthalate, mBP).
Median concentrations in colostrum were higher, although not statistically significantly, in cryptorchid versus controls. Cryptorchid boys were more likely to be classified in the most contaminated groups in colostrum for DDE, Sigma PCBs and the composite score PCB + DDE. The same trend, but again not statistically significantly was observed for mBP. Odds ratio for cryptorchidism was increased for the highest score of Sigma PCB, with a trend only for DDE and Sigma PCB + DDE versus the lowest score of those components.
Our results support an association between congenital cryptorchidism and fetal exposure to PCBs and possibly DDE. Higher concentrations in milk could be a marker of higher exposure or for an impaired detoxification pattern in genetically predisposed individuals.
由于胎儿暴露于抗雄激素和/或雌激素化合物会对动物繁殖产生不利影响，因此这种暴露可能对人类胎儿有害。关于隐睾症与人类接触内分泌干扰物的数据很少。
我们进行了一项前瞻性病例对照研究，以评估法国尼斯地区隐睾症的发病率以及胎儿暴露于特定化学物质的情况。对151份脐带血（67例隐睾症患者，84例紧密匹配的对照）和125份初乳（56份来自隐睾症患者，69份来自对照）进行了筛选，检测其中的外源性物质，包括抗雄激素的二氯二苯三氯乙烷（DDE）、多氯联苯（PCBs）和邻苯二甲酸二丁酯（及其代谢产物单丁基邻苯二甲酸酯，mBP）。
初乳中各物质的中位数浓度在隐睾症患者中虽高于对照组，但无统计学显著差异。在初乳中，隐睾症男孩更有可能被归类为DDE、总多氯联苯以及多氯联苯+DDE综合评分污染最严重的组。mBP也呈现相同趋势，但同样无统计学显著差异。总多氯联苯得分最高时，隐睾症的比值比增加，DDE和总多氯联苯+DDE仅呈现与这些成分最低得分相比的趋势。
我们的结果支持先天性隐睾症与胎儿暴露于多氯联苯以及可能的DDE之间存在关联。乳汁中较高的浓度可能是高暴露的标志，或者是遗传易感性个体解毒模式受损的标志。
