Kaliviotis Efstathios, Yianneskis Michael
Experimental and Computational Laboratory for the Analysis of Turbulence (ECLAT), Division of Engineering, King's College London, Strand, UK.
Clin Hemorheol Microcirc. 2008;39(1-4):235-42.
Red blood cell aggregation affects the flow of blood at low shear rates; not only the behaviour of the fluid deviates from its Newtonian characteristics, but, depending on the shearing history of the flow, the non-Newtonian characteristics may be influenced. It is not clear how the time and flow-dependent characteristics of the microstructural network developed in blood affect its mechanical properties. The present study aims to improve understanding of the effect of dynamic flow conditions on microstructural characteristics and consequently on the mechanical properties of the fluid. Viscosity measurements on blood samples from healthy volunteers (H=0.45) were taken with a double-walled Couette rheometric cell, under unsteady and quasi-unsteady flow conditions. The aggregation extent index A(alpha), and the microstructural integrity index A(I) were assessed with an optical shearing system and image analysis. Results showed that energy losses in Couette geometries may depend on the structural integrity of the developed RBC network.
红细胞聚集会影响低剪切速率下的血液流动；不仅流体的行为偏离其牛顿特性，而且根据流动的剪切历史，非牛顿特性可能会受到影响。目前尚不清楚血液中形成的微观结构网络的时间和流量依赖性特征如何影响其力学性能。本研究旨在增进对动态流动条件对微观结构特征进而对流体力学性能影响的理解。使用双壁库埃特流变仪池，在非稳态和准非稳态流动条件下，对健康志愿者的血液样本（H = 0.45）进行粘度测量。使用光学剪切系统和图像分析评估聚集程度指数A(α)和微观结构完整性指数A(I)。结果表明，库埃特几何形状中的能量损失可能取决于所形成的红细胞网络的结构完整性。
