Oudshoorn C, Mattace-Raso F U S, van der Velde N, Colin E M, van der Cammen T J M
Department of Internal Medicine, Section of Geriatric Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Dement Geriatr Cogn Disord. 2008;25(6):539-43. doi: 10.1159/000134382. Epub 2008 May 26.
BACKGROUND/AIMS: Recent studies suggest that vitamin D metabolites may be important for preserving cognitive function via specific neuroprotective effects. No large studies have examined the association between vitamin D status and cognition.
In this cross-sectional study, we analyzed the serum 25-hydroxyvitamin D(3) levels and Mini-Mental State Examination (MMSE) test scores of 225 older outpatients who were diagnosed as having probable Alzheimer's disease (AD). In addition to the 25-hydroxyvitamin D(3) levels, we analyzed the serum vitamin B(1), B(6) and B(12) levels.
An association was found between MMSE test scores and serum 25-hydroxyvitamin D(3) levels, with a beta-coefficient of 0.05 (p = 0.01). Vitamin-D-sufficient patients had significantly higher MMSE scores as compared to vitamin-D-insufficient ones. No association was found with the other serum vitamin levels.
These data support the idea that a relationship exists between vitamin D status and cognition in patients with probable AD. However, given the cross-sectional design of this study, no causality can be concluded. Further prospective studies are needed to specify the contribution of vitamin D status to the onset and course of cognitive decline and AD.
背景/目的：近期研究表明，维生素D代谢产物可能通过特定的神经保护作用对维持认知功能具有重要意义。尚无大型研究探讨维生素D水平与认知之间的关联。
在这项横断面研究中，我们分析了225名被诊断为可能患有阿尔茨海默病（AD）的老年门诊患者的血清25-羟基维生素D(3)水平和简易精神状态检查表（MMSE）测试得分。除了25-羟基维生素D(3)水平外，我们还分析了血清维生素B(1)、B(6)和B(12)水平。
发现MMSE测试得分与血清25-羟基维生素D(3)水平之间存在关联，β系数为0.05（p = 0.01）。维生素D充足的患者的MMSE得分显著高于维生素D不足的患者。未发现与其他血清维生素水平存在关联。
这些数据支持了可能患有AD的患者的维生素D水平与认知之间存在关联这一观点。然而，鉴于本研究的横断面设计，无法得出因果关系。需要进一步的前瞻性研究来明确维生素D水平对认知衰退和AD的发病及病程的影响。
