Kong Alice P S, Choi Kai-Chow, Ko Gary T C, Wong Gary W K, Ozaki Risa, So Wing-Yee, Tong Peter C Y, Chan Juliana C N
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Pediatr Diabetes. 2008 Oct;9(5):488-95. doi: 10.1111/j.1399-5448.2008.00410.x. Epub 2008 May 22.
Obesity is a growing global health problem. Obesity-associated inflammatory and metabolic consequences may vary in different ethnic populations, and data in Chinese adolescents are sparse. In this study, we analysed the clinical and biochemical factors associated with overweight and obesity in Chinese adolescents.
This is a cross-sectional cohort study with 2102 Chinese adolescents randomly selected from 14 secondary schools in Hong Kong. Clinical and biochemical parameters including inflammatory markers, among different groups stratified by degrees of obesity, were compared by multivariate logistic regression analysis.
The median age was 16 yr (interquartile range: 14-17 yr) (45.6% boys and 54.4% girls). Among the boys, 16.5% were overweight and 6.8% were obese. The respective percentages in girls were 8.2 and 5.8%. Compared with the group with normal weight in both boys and girls, high systolic blood pressure (SBP), increased insulin resistance (by homoeostasis model assessment, HOMA-IR), elevated high-sensitivity C-reactive protein (hsCRP) level and low high-density lipoprotein cholesterol (HDL-C) level were independently associated with overweight/obesity. In boys, the respective odds ratio (95% CI) was 1.03 (1.01-1.05) for SBP, 21.0 (12.0-36.8) for HOMA-IR, 3.65 (2.10-6.35) for hsCRP and 0.24 (0.11-0.51) for HDL-C. In girls, the respective figures were 1.02 (1.00-1.04), 9.82 (5.65-17.1), 6.28 (3.12-12.6) and 0.18 (0.08-0.41). In girls, low-density lipoprotein cholesterol was also independently associated with overweight/obesity [1.56 (1.09-2.24)].
In Chinese adolescents, overweight/obesity is independently associated with SBP, insulin resistance, hsCRP and low HDL-C. Early intervention in overweight and obese adolescents may potentially retard the development of these cardiovascular risk factors.
肥胖是一个日益严重的全球健康问题。肥胖相关的炎症和代谢后果在不同种族人群中可能有所不同，而中国青少年的数据较为匮乏。在本研究中，我们分析了与中国青少年超重和肥胖相关的临床和生化因素。
这是一项横断面队列研究，从香港14所中学随机选取2102名中国青少年。通过多因素逻辑回归分析比较了不同肥胖程度分层组之间的临床和生化参数，包括炎症标志物。
中位年龄为16岁（四分位间距：14 - 17岁）（男孩占45.6%，女孩占54.4%）。男孩中，16.5%超重，6.8%肥胖。女孩中的相应比例分别为8.2%和5.8%。与体重正常组相比，收缩压（SBP）升高、胰岛素抵抗增加（通过稳态模型评估，HOMA - IR）、高敏C反应蛋白（hsCRP）水平升高和高密度脂蛋白胆固醇（HDL - C）水平降低与超重/肥胖独立相关。在男孩中，SBP的比值比（95%可信区间）为1.03（1.01 - 1.05），HOMA - IR为21.0（12.0 - 36.8），hsCRP为3.65（2.10 - 6.35），HDL - C为0.24（0.11 - 0.51）。在女孩中，相应数字分别为1.02（1.00 - 1.04）、9.82（5.65 - 17.1）、6.28（3.12 - 12.6）和0.18（0.08 - 0.41）。在女孩中，低密度脂蛋白胆固醇也与超重/肥胖独立相关[1.56（1.09 - 2.24）]。
在中国青少年中，超重/肥胖与SBP、胰岛素抵抗、hsCRP和低HDL - C独立相关。对超重和肥胖青少年进行早期干预可能会延缓这些心血管危险因素的发展。
