Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Italy.
Department of Experimental Medicine, Sapienza University of Rome, Italy.
Nutr Metab Cardiovasc Dis. 2014 Jul;24(7):737-43. doi: 10.1016/j.numecd.2014.01.010. Epub 2014 Jan 29.
The triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. We evaluated in a large sample of children and adolescents the association of TG/HDL-C ratio with early signs of morphological vascular changes and cardiometabolic risk factors including nonalcoholic fatty liver disease (NAFLD).
The study population, including 548 children (aged 6-16 years), of whom 157 were normal-weight, 118 overweight, and 273 obese, had anthropometric, laboratory, liver and carotid ultrasonography (carotid artery intima-media thickness-cIMT) data collected. Subjects were stratified into tertiles of TG/HDL-C. There was a progressive increase in body mass index (BMI), BMI-SD score (SDS), waist circumference, blood pressure (BP), liver enzymes, glucose, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein (hsCRP), and cIMT values across TG/HDL-C tertiles. The odds ratios for central obesity, insulin resistance, high hsCRP, NAFLD, metabolic syndrome, and elevated cIMT increased significantly with the increasing tertile of TG/HDL-C ratio, after adjustment for age, gender, pubertal status, and BMI-SDS. In a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08-3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03-15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30-3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62-4.56); P < 0.01].
TG/HDL-C ratio may help identify children and adolescents at high risk for structural vascular changes and metabolic derangement.
甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）比值已被报道为一种有用的动脉粥样硬化脂质异常、胰岛素抵抗和心血管疾病的标志物。我们在大量儿童和青少年中评估了 TG/HDL-C 比值与形态学血管变化的早期迹象以及包括非酒精性脂肪肝（NAFLD）在内的代谢危险因素之间的关联。
研究人群包括 548 名儿童（年龄 6-16 岁），其中 157 名体重正常，118 名超重，273 名肥胖，收集了人体测量学、实验室、肝脏和颈动脉超声（颈动脉内膜中层厚度-cIMT）数据。受试者根据 TG/HDL-C 三分位值进行分层。随着 TG/HDL-C 三分位值的升高，体重指数（BMI）、BMI-SD 评分（SDS）、腰围、血压（BP）、肝酶、血糖、胰岛素、胰岛素抵抗稳态模型评估、高敏 C 反应蛋白（hsCRP）和 cIMT 值均呈逐渐升高趋势。在校正年龄、性别、青春期状态和 BMI-SDS 后，随着 TG/HDL-C 比值三分位值的升高，中心性肥胖、胰岛素抵抗、高 hsCRP、NAFLD、代谢综合征和 cIMT 升高的比值比显著增加。在逐步多元逻辑回归分析中，增加的 cIMT 与高 TG/HDL-C 比值相关[比值比，1.81（95%可信区间，1.08-3.04）；P<0.05]，升高的血压[5.13（95%可信区间，1.03-15.08）；P<0.05]，胰岛素抵抗[2.16（95%可信区间，1.30-3.39）；P<0.01]和 NAFLD[2.70（95%可信区间，1.62-4.56）；P<0.01]。
TG/HDL-C 比值有助于识别发生结构血管变化和代谢紊乱风险较高的儿童和青少年。
