决定生物活性白细胞介素-12形成与释放的因素：白细胞介素-12p70合成与抑制的调控机制
Factors determining the formation and release of bioactive IL-12: regulatory mechanisms for IL-12p70 synthesis and inhibition.
作者信息
Zhang Sheng, Wang Qin
机构信息
Medical Oncology, First People's Hospital, Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China.
出版信息
Biochem Biophys Res Commun. 2008 Aug 8;372(4):509-12. doi: 10.1016/j.bbrc.2008.05.081. Epub 2008 May 27.
IL-12 is an important type 1 immune activation cytokine. It is known that macrophages and dendritic cells the major cell types producing this cytokine and that these cells may release both the biologically inactive form (IL-12p40) and active form (IL-12p70) of IL-12. In this review, the latest information regarding the regulatory mechanisms governing the production of IL-12p70 by these cells is evaluated.
白细胞介素-12是一种重要的1型免疫激活细胞因子。已知巨噬细胞和树突状细胞是产生这种细胞因子的主要细胞类型，并且这些细胞可能释放白细胞介素-12的生物无活性形式（白细胞介素-12p40）和活性形式（白细胞介素-12p70）。在本综述中，评估了关于这些细胞产生白细胞介素-12p70的调控机制的最新信息。
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