Dickinson A M, Holler E
School of Clinical and Laboratory Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.
Best Pract Res Clin Haematol. 2008 Jun;21(2):149-64. doi: 10.1016/j.beha.2008.03.004.
In the last 10 years, non-HLA genotypes have been investigated for their potential roles in the occurrence and severity of graft-versus-host disease (GVHD) as well as for their contribution to overall transplant-related mortality, infectious episodes, and overall survival. This chapter will review the latest results of cytokine gene polymorphisms between patient and donor which may cause the production of high or low levels of cytokines during the three-stage process of the GVHD 'cytokine storm'. More recent investigations into innate immunity and the interaction with subsequent downstream cytokine production and ultimate tissue damage are discussed. The potential of these non-HLA genetics to aid in predicting GVHD and post-transplant survival and the relevance of this information to the clinic are reviewed.
在过去10年中，人们对非人类白细胞抗原（HLA）基因型在移植物抗宿主病（GVHD）的发生和严重程度方面的潜在作用进行了研究，同时也研究了它们对总体移植相关死亡率、感染发作和总生存率的影响。本章将回顾患者与供体之间细胞因子基因多态性的最新研究结果，这些多态性可能在GVHD“细胞因子风暴”的三个阶段过程中导致细胞因子产生水平的高低变化。还将讨论对固有免疫以及与后续下游细胞因子产生和最终组织损伤之间相互作用的最新研究。本文回顾了这些非HLA基因在预测GVHD和移植后生存率方面的潜力以及该信息与临床的相关性。
