Dickinson A M
School of Clinical and Laboratory Sciences, The Medical School, Newcastle University, Newcastle upon Tyne, UK.
Int J Immunogenet. 2008 Aug;35(4-5):375-80. doi: 10.1111/j.1744-313X.2008.00790.x.
Over the last 10 years, an increasing number of studies have demonstrated the role of non-human leukocyte antigen (HLA) genes in predicting outcome in haematopoietic stem cell transplantation (HSCT). These studies have included investigations into 'single nucleotide polymorphisms (SNPs)' or microsatellites of cytokines, cytokine receptor genes, or genes associating with innate immunity. These polymorphisms give rise to functional differences in the production of e.g. cytokines, or altered function of genes which are reflected in potential up- or down- regulating of the 'cytokine storm' of GvHD. This review summarises some of the studies and relates the results to their potential for improving HSCT outcome by predicting transplant-related mortality and GvHD.
在过去10年中，越来越多的研究表明非人类白细胞抗原（HLA）基因在预测造血干细胞移植（HSCT）结局方面的作用。这些研究包括对细胞因子、细胞因子受体基因或与先天免疫相关基因的“单核苷酸多态性（SNP）”或微卫星的研究。这些多态性导致例如细胞因子产生的功能差异，或基因功能改变，这反映在移植物抗宿主病（GvHD）“细胞因子风暴”的潜在上调或下调中。本综述总结了一些研究，并将结果与其通过预测移植相关死亡率和GvHD来改善HSCT结局的潜力相关联。
