Diaconu Gabriel, Turecki Gustavo
McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montréal, Québec, Canada.
J Affect Disord. 2009 Feb;113(1-2):172-8. doi: 10.1016/j.jad.2008.03.028. Epub 2008 May 27.
Impulsive-aggressive traits have been proposed as mediators of the transmission of suicidal behavior in families. Our aim was to investigate the association between family history of suicidal behavior, and expressions of impulsivity and aggressive behavior, in a clinical population.
A sample of n=474 psychiatric outpatient subjects were assessed by means of standardized interviews for Axis I and II psychopathology, history of suicidal behavior in subjects and their family, and measures of impulsive-aggressive behaviors (IAB).
A total of n=38 (8%) probands had a family history of suicidal behavior. This was three times more frequent in patients with a personal history of suicidality, irrespective of their own psychopathology (p<0.001), and four times more frequent in suicide attempters with depression vs. depressed non-attempters (p<0.005). A family history of suicidal behavior was associated with higher impulsive (p<0.005) and aggressive behavior measures (p<0.01) in probands.
Retrospective design and family-history methodology; Limited sample; Contagion and imitation effects could not be assessed based on available data.
Impulsive-aggressive behaviors are significantly elevated in persons who have a familial loading of suicidal behavior.
冲动攻击特质被认为是家庭中自杀行为传播的中介因素。我们的目的是在临床人群中研究自杀行为家族史与冲动性及攻击行为表现之间的关联。
对n = 474名精神科门诊患者进行抽样评估，采用标准化访谈评估轴I和轴II精神病理学、患者及其家族的自杀行为史以及冲动攻击行为（IAB）测量。
共有n = 38名（8%）先证者有自杀行为家族史。无论其自身精神病理学情况如何，有自杀个人史的患者中这一比例是无自杀个人史患者的三倍（p < 0.001），与无自杀未遂的抑郁症患者相比，自杀未遂的抑郁症患者中这一比例是其四倍（p < 0.005）。先证者的自杀行为家族史与更高的冲动性测量值（p < 0.005）和攻击行为测量值（p < 0.01）相关。
回顾性设计和家族史研究方法；样本有限；无法根据现有数据评估传染和模仿效应。
有自杀行为家族遗传倾向的个体，其冲动攻击行为显著增加。
