Mahmoudi Mitra, Morteza-Semnani Katayoun, Mojra Elham
Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Fitoterapia. 2008 Jul;79(5):361-5. doi: 10.1016/j.fitote.2008.04.004. Epub 2008 May 27.
Thymus pubescens is an aromatic and medicinal plant, which has been widely distributed in Iran. The anti-inflammatory and analgesic effects of the T. pubescens aerial parts methanol extract were studied at doses of 50-400 mg/kg i.p. using carrageenan-induced edema, formalin, hot plate and writhing tests. The extract produced a significant decrease in the degree of swelling, 3 h after carrageenan injection and caused graded inhibition of both phases of formalin-induced pain. Moreover, in the hot plate test, it significantly raised the pain threshold. While in the writhing test produced a significant decrease in the number of writhing in comparison with the control group (P<0.001). The results of pharmacological tests performed in the present study suggest that the extract of T. pubescens presents analgesic and anti-inflammatory effects.
柔毛百里香是一种芳香药用植物，广泛分布于伊朗。采用角叉菜胶诱导的水肿、福尔马林、热板和扭体试验，研究了柔毛百里香地上部分甲醇提取物在50 - 400 mg/kg腹腔注射剂量下的抗炎和镇痛作用。提取物在角叉菜胶注射后3小时显著降低肿胀程度，并对福尔马林诱导疼痛的两个阶段产生分级抑制。此外，在热板试验中，它显著提高了痛阈。而在扭体试验中，与对照组相比，扭体次数显著减少（P<0.001）。本研究进行的药理试验结果表明，柔毛百里香提取物具有镇痛和抗炎作用。
