Shin Mal-Soon, Kim Su-Kyung, Kim Youn-Sub, Kim Sung-Eun, Ko Il-Gyu, Kim Young-Sick, Kim Chang-Ju, Kim You-Mi, Kim Bo-Kyun, Kim Tae-Soo
Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
Fitoterapia. 2008 Jul;79(5):323-7. doi: 10.1016/j.fitote.2008.02.014. Epub 2008 Apr 18.
In this study, the effects of the aqueous extract of Anemarrhena rhizome on cell proliferation and neuropeptide Y expression in the dentate gyrus of streptozotocin-induced diabetic rats were investigated via immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) and neuropeptide Y. The results showed that the treatment with 50 to 200 microg/kg/day for 7 days of the aqueous extract of Anemarrhena rhizome increased new cell formation and neuropeptide Y expression in the dentate gyrus of diabetic rats reduced by the treatment with streptozotocin in rat.
本研究通过对5-溴-2'-脱氧尿苷（BrdU）和神经肽Y进行免疫组织化学检测，研究知母水提取物对链脲佐菌素诱导的糖尿病大鼠齿状回中细胞增殖和神经肽Y表达的影响。结果显示，以50至200微克/千克/天的剂量给予知母水提取物处理7天，可增加糖尿病大鼠齿状回中的新细胞形成，并提高神经肽Y的表达，而链脲佐菌素处理会降低大鼠的这些指标。
