[非小细胞肺癌患者中P53蛋白表达与顺铂化疗敏感性的Meta分析]
[P53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer: a meta-analysis].
作者信息
Wang Jin-liang, Jiao Shun-chang, Ye Ping, Li Jin-yu
机构信息
Department of Medical Oncology, General Hospital of PLA, Beijing 100853, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2008 May;28(5):770-3.
OBJECTIVE
To explore the relation between p53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer (NSCLC).
METHODS
The DerSimonian-Laird random effect model was used to analyze the data reported in relevant literature.
RESULTS
Sixteen trials involving 1070 patients were retrieved. The overall positivity rate of p53 was 50.4% and overall response rate to cisplatin was 38.7%. The test for heterogeneity showed that all eligible studies had heterogeneity (chi 2-/+47.57, P<0.0001). The combined odds ratio (OR) was 1.37, with 95% confidence interval of 0.84-2.24.
CONCLUSION
Expression of p53 protein in patients with NSCLC is not associated with the chemosensitivity to cisplatin.
目的
探讨非小细胞肺癌（NSCLC）患者p53蛋白表达与对顺铂化疗敏感性之间的关系。
方法
采用DerSimonian-Laird随机效应模型分析相关文献报道的数据。
结果
检索到16项试验，涉及1070例患者。p53总体阳性率为50.4%，对顺铂的总体缓解率为38.7%。异质性检验表明，所有符合条件的研究均存在异质性（χ²=47.57，P<0.0001）。合并比值比（OR）为1.37，95%置信区间为0.84-2.24。
结论
NSCLC患者p53蛋白表达与对顺铂的化疗敏感性无关。
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