Aggarwal N, Suri V, Soni S, Chopra V, Kohli H S
Department of Obstetrics & Gynecology, PGIMER, Chandigarh, India.
Medscape J Med. 2008 Apr 22;10(4):98.
To assess the diagnostic accuracy of random urine protein-creatinine ratio for the prediction of significant proteinuria in patients with preeclampsia.
155 pregnant patients diagnosed to have hypertension in late pregnancy were instructed to collect urine during a 24-hour period. Protein-creatinine ratio was evaluated in a random urinary specimen. Out of these, 120 patients fulfilled the inclusion criteria. The predictive value of the random urinary protein-creatinine ratio for the diagnosis of significant proteinuria was estimated by using a 300-mg protein level within the collected 24-hour urine as the gold standard.
104 patients (86.67%) had significant proteinuria. There was significant association between 24-hour protein excretion and the random urine protein-creatinine ratio (r(s)=0.596, P < .01). With a cut-off protein-creatinine ratio greater than 1.14 as a predictor of significant proteinuria, sensitivity and specificity were 72% and 75%, respectively. The positive predictive value was 94.9% and negative predictive value was 29.2%.
The random urine protein-creatinine ratio was not a good predictor of significant proteinuria in patients with preeclampsia.
评估随机尿蛋白肌酐比值对预测子痫前期患者严重蛋白尿的诊断准确性。
155例被诊断为妊娠晚期高血压的孕妇被要求在24小时内收集尿液。对一份随机尿标本进行蛋白肌酐比值评估。其中，120例患者符合纳入标准。以收集的24小时尿液中蛋白质水平300毫克作为金标准，评估随机尿蛋白肌酐比值对诊断严重蛋白尿的预测价值。
104例患者（86.67%）有严重蛋白尿。24小时蛋白排泄量与随机尿蛋白肌酐比值之间存在显著相关性（r(s)=0.596，P <.01）。以蛋白肌酐比值大于1.14作为严重蛋白尿的预测指标，敏感性和特异性分别为72%和75%。阳性预测值为94.9%，阴性预测值为29.2%。
随机尿蛋白肌酐比值不是子痫前期患者严重蛋白尿的良好预测指标。
