Department of Obstetrics and Gynecology, Lehigh Valley Health Network, Allentown, PA.
Am J Obstet Gynecol. 2012 Sep;207(3):233.e1-8. doi: 10.1016/j.ajog.2012.06.010. Epub 2012 Jun 11.
The purpose of this study was to evaluate the performance of the 12-hour urine protein >165 mg and protein:creatinine ratio >0.15 for the prediction of 24-hour urine protein of ≥300 mg in patients with suspected preeclampsia.
We performed a prospective observational study of 90 women who had been admitted with suspected preeclampsia. Protein:creatinine ratio and 12- and 24-hour urine specimens were collected for each patient. Test characteristics for the identification of 24-hour urine protein ≥300 mg were calculated.
A 12-hour urine protein >165 mg and protein:creatinine ratio of >0.15 correlated significantly with 24-hour urine protein ≥300 mg (r = 0.99; P < .001; and r = 0.54; P < .001, respectively). A 12-hour urine protein >165 mg performed better than protein:creatinine ratio as a predictor of a 24-hour urine protein ≥300 mg (sensitivity, 96% and 89%; specificity, 100% and 49%; positive predictive value, 100% and 32%; negative predictive value, 98% and 91%, respectively).
The high correlation of a 12-hour urine protein >165 mg with a 24-hour urine protein ≥300 mg (with the benefit of a shorter evaluation time) and the high negative predictive value of protein:creatinine ratio suggest that the use of both these tests have a role in the evaluation and treatment of women with suspected preeclampsia.
本研究旨在评估 12 小时尿液蛋白>165mg 和蛋白/肌酐比值>0.15 对预测疑似子痫前期患者 24 小时尿蛋白≥300mg 的性能。
我们对 90 名疑似子痫前期患者进行了前瞻性观察研究。对每位患者收集了蛋白/肌酐比值和 12 小时及 24 小时尿液标本。计算了用于识别 24 小时尿蛋白≥300mg 的检验特征。
12 小时尿液蛋白>165mg 和蛋白/肌酐比值>0.15 与 24 小时尿蛋白≥300mg 显著相关（r=0.99；P<.001；r=0.54；P<.001）。12 小时尿液蛋白>165mg 作为预测 24 小时尿蛋白≥300mg 的指标优于蛋白/肌酐比值（敏感性分别为 96%和 89%；特异性分别为 100%和 49%；阳性预测值分别为 100%和 32%；阴性预测值分别为 98%和 91%）。
12 小时尿液蛋白>165mg 与 24 小时尿蛋白≥300mg 具有高度相关性（具有较短评估时间的优势），且蛋白/肌酐比值具有较高的阴性预测值，提示这两种检测方法在疑似子痫前期患者的评估和治疗中均有作用。
