Ghaleb Amr M, Yang Vincent W
Curr Colorectal Cancer Rep. 2008 Apr;4(2):59-64. doi: 10.1007/s11888-008-0011-4.
The Krüppel-like factor (KLF) proteins are zinc finger-containing transcription factors that exert important functions in regulating diverse biologic processes such as growth, proliferation, differentiation, development, inflammation, and apoptosis. Many KLFs have also been shown to play significant roles in tumorigenesis of various organs and tissues. Three in particular-KLF4, KLF5, and KLF6-are often dysregulated in tumors of the gastrointestinal tract, including colorectal cancer. This article reviews the functions of these three KLFs in normal gastrointestinal biology and their pathobiologic roles in colorectal cancer.
Krüppel样因子（KLF）蛋白是含锌指结构的转录因子，在调节多种生物学过程如生长、增殖、分化、发育、炎症和凋亡中发挥重要作用。许多KLF蛋白也已被证明在各种器官和组织的肿瘤发生中起重要作用。特别是KLF4、KLF5和KLF6这三种蛋白，在包括结直肠癌在内的胃肠道肿瘤中常常表达失调。本文综述了这三种KLF蛋白在正常胃肠道生物学中的功能及其在结直肠癌中的病理生物学作用。
