De Luca Vincenzo, Tharmaligam Subi, Strauss John, Kennedy James L
Dept. of Psychiatry, University of Toronto, 250 College Street, R-30, Toronto (ON), Canada M5T 1R8.
Eur Arch Psychiatry Clin Neurosci. 2008 Oct;258(7):428-33. doi: 10.1007/s00406-008-0815-x. Epub 2008 May 26.
The serotonin 2C (HTR2C) receptor has been implicated in suicide-related behaviours, however there are not many studies to date about HTR2C and suicidality. We studied HTR2C haplotypes in suicide attempters, where our sample composed of 306 families with at least one member affected by bipolar disorder. HTR2C (Cys23Ser and a common STR in the promoter) variants were analyzed with respect to attempter status and the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder.
血清素2C（HTR2C）受体与自杀相关行为有关，然而，迄今为止关于HTR2C与自杀倾向的研究并不多。我们研究了自杀未遂者的HTR2C单倍型，我们的样本由306个家庭组成，这些家庭中至少有一名成员患有双相情感障碍。针对未遂者状态和自杀行为的严重程度分析了HTR2C（Cys23Ser和启动子中的一个常见STR）变体。与自杀未遂相关的X连锁单倍型分析未发现任何显著关联。此外，我们对X连锁血清素能基因（HTR2C和MAOA）进行了特定的基因-基因相互作用分析，发现这种基因间单倍型组合与双相情感障碍中的自杀行为之间没有关联。
