Karanović Jelena, Šviković Saša, Pantović Maja, Durica Svetlana, Brajušković Goran, Damjanović Aleksandar, Jovanović Vladimir, Ivković Maja, Romac Stanka, Savić Pavićević Dušanka
Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade , Belgrade , Serbia.
World J Biol Psychiatry. 2015 Jun;16(4):261-71. doi: 10.3109/15622975.2014.1000374. Epub 2015 Mar 2.
Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability.
Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory-Self Report and List of Threatening Experiences Questionnaire, respectively. Selected ADAR and ADARB1 tag-variants, and HTR2C rs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors.
ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse.
SA vulnerability in psychiatric patients is related to the joint effect of ADARB1 and HTR2C variants, the existing mood disorder and the cumulative exposures to a various childhood and recent stressful experiences.
腺苷到肌苷的RNA编辑、5-羟色胺2C受体（HTR2C）以及应激性生活事件（SLEs）均与自杀行为有关。我们研究了RNA编辑（ADAR、ADARB1）和HTR2C基因、童年创伤（CT）、近期SLEs以及精神障碍作为自杀未遂（SA）易感性影响因素的主要和调节作用。
研究纳入了165名自杀未遂者和188名非自杀未遂者，所有参与者均被诊断患有一种主要精神障碍。分别使用早期创伤量表-自我报告和威胁性经历问卷列表对CT和近期SLEs进行评估。对选定的ADAR和ADARB1标签变体以及HTR2C rs6318进行与SA相关性的预筛查，同时应用广义线性模型和向后选择来识别个体及相互作用的SA风险因素。
ADARB1 rs9983925和rs4819035以及HTR2C rs6318与SA相关。最佳简约模型发现情感虐待、近期SLEs、rs9983925和rs6318为独立的SA风险因素，而一般创伤是调节精神障碍和情感虐待作用的一个因素。
精神科患者的SA易感性与ADARB1和HTR2C变体的联合作用、现患情绪障碍以及童年和近期各种应激经历的累积暴露有关。
