Szucs-Farkas Zsolt, Froehlich Johannes M, Ulrich Martin, Wuersten Hans-Ueli, Guignard Dominique, Wyss Sandra, Braunschweig Marianne
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University of Berne, Berne, Switzerland.
J Magn Reson Imaging. 2008 Jun;27(6):1399-405. doi: 10.1002/jmri.21351.
To perform a quantitative and qualitative comparison of gadobutrol and gadoterate in three-station contrast enhanced magnetic resonance angiography (CE-MRA) of the lower limbs.
In this prospective randomized controlled trial, 52 patients with leg ischemia were randomly assigned to one of two groups receiving either gadobutrol (1.0 mmol Gd/mL, 15 mL) or gadoterate (0.5 mmol Gd/mL, 30 mL). Three-station 3D CE-MRAs from the pelvis to the ankles were performed with moving-table technique on a 1.5T MR scanner. Injection time was identical in both groups. Signal-to-noise (SNR) and contrast-to-noise ratios (CNR) were calculated for 816 arteries. Contrast quality in 1196 vessel segments was evaluated separately by two blinded readers on a three-point scale.
Mean SNR (61.8 +/- 7.8 for gadobutrol vs. 61.9 +/- 9.1 for gadoterate, P = 0.257), CNR (52.8 +/- 9.1 vs. 52.8 +/- 10.7, P = 0.154), and qualitative ranking (1.41 vs. 1.44, P = 0.21) for all vessels did not differ significantly between the two patient groups. The overall quality was good in 90.4% with gadoterate and 94.2% with gadobutrol (P = 0.462).
High-concentration gadobutrol allows neither a higher CNR nor any qualitative advantage over the ordinary unspecific Gd agent gadoterate when the same Gd load and injection times are used in multistation CE-MRA of the peripheral arteries.
对钆布醇和钆特酸葡胺在下肢三部位对比增强磁共振血管造影（CE-MRA）中的定量和定性进行比较。
在这项前瞻性随机对照试验中，52例腿部缺血患者被随机分为两组，分别接受钆布醇（1.0 mmol钆/毫升，15毫升）或钆特酸葡胺（0.5 mmol钆/毫升，30毫升）。在1.5T磁共振扫描仪上采用移动检查床技术对从骨盆至脚踝的三个部位进行三维CE-MRA检查。两组的注射时间相同。计算816条动脉的信噪比（SNR）和对比噪声比（CNR）。由两名不知情的阅片者分别以三点量表对1196个血管节段的对比质量进行评估。
两组患者所有血管的平均SNR（钆布醇组为61.8±7.8，钆特酸葡胺组为61.9±9.1，P = 0.257）、CNR（52.8±9.1 vs. 52.8±10.7，P = 0.154）和定性分级（1.41 vs. 1.44，P = 0.21）差异均无统计学意义。钆特酸葡胺组总体质量良好的比例为90.4%，钆布醇组为94.2%（P = 0.462）。
在周围动脉多部位CE-MRA中，当使用相同的钆负荷和注射时间时，高浓度钆布醇与普通非特异性钆剂钆特酸葡胺相比，既不能获得更高的CNR，也没有任何定性优势。
