Landman G W D, Ubink-Veltmaat L J, Kleefstra N, Kollen B J, Bilo H J G
Diabetes Centre, Isala Clinics, Zwolle, The Netherlands.
Anticancer Res. 2008 Mar-Apr;28(2B):1373-5.
It is unclear whether there is a relationship between type two diabetes and cancer mortality. It also is unclear whether obesity and body mass index (BMI) are associated with cancer in type 2 diabetes patients.
In 1998, 1,145 patients with type two diabetes mellitus were enrolled in the Zwolle Outpatient Diabetes project Intergrating Available Care (ZODIAC) study. In this project, general practitioners (GPs) were assisted by hospital-based diabetes specialist nurses. Vital status was assessed in September 2004. The cancer mortality rate was evaluated using standardized mortality ratio (SMR) and its association with BMI (kg/m2) and obesity (>30 kg/m2) with the Cox proportional hazard ratio.
The median follow-up time was 5.8 years. A total of 335 patients had died, of whom 70 died from malignancy. The SMR for cancer mortality was 1.38 (95% CI 1.07-1.75). BMI and obesity were not associated with cancer death.
An increased cancer mortality rate was found in type two diabetes mellitus patients but there was no significant association between BMI or obesity and cancer mortality.
尚不清楚2型糖尿病与癌症死亡率之间是否存在关联。同样不清楚肥胖和体重指数（BMI）是否与2型糖尿病患者的癌症相关。
1998年，1145例2型糖尿病患者纳入兹沃勒门诊糖尿病综合可用护理项目（ZODIAC）研究。在该项目中，全科医生（GPs）由医院的糖尿病专科护士协助。2004年9月评估生命状态。使用标准化死亡率（SMR）评估癌症死亡率，并通过Cox比例风险比评估其与BMI（kg/m²）和肥胖（>30 kg/m²）的关联。
中位随访时间为5.8年。共有335例患者死亡，其中70例死于恶性肿瘤。癌症死亡率的SMR为1.38（95%CI 1.07 - 1.75）。BMI和肥胖与癌症死亡无关。
2型糖尿病患者的癌症死亡率有所增加，但BMI或肥胖与癌症死亡率之间无显著关联。
