Ioannidis Ioannis
Diabetes and Obesity Outpatient Clinic, Konstantopoulio Hospital, Athens, Greece.
Angiology. 2008 Apr-May;59(2 Suppl):39S-43S. doi: 10.1177/0003319708318583. Epub 2008 May 27.
It is well known that the relative risk of developing type 2 diabetes mellitus increases with increasing body mass index. The presence of not only excessive body fat but also the pattern of fat distribution (central obesity) is important for other metabolic abnormalities included in the metabolic syndrome. The possible mechanisms linking obesity to type 2 diabetes including high concentrations of free fatty acids, altered adipokines expression (low adiponectin levels and high expression of tumor necrosis factor-alpha), and low-grade inflammation are reviewed. Finally, the author refers to the theory that the primary defect is beta-cell failure that leads to diabetes as well as to obesity.
众所周知，随着体重指数的增加，患2型糖尿病的相对风险也会增加。不仅过多的体脂存在，而且脂肪分布模式（中心性肥胖）对于代谢综合征中包含的其他代谢异常也很重要。本文综述了肥胖与2型糖尿病相关的可能机制，包括高浓度游离脂肪酸、脂肪因子表达改变（脂联素水平低和肿瘤坏死因子-α高表达）以及低度炎症。最后，作者提到了一种理论，即原发性缺陷是导致糖尿病以及肥胖的β细胞功能衰竭。
