Sahin Mehmet, Sahin Emel, Gümüslü Saadet
Department of Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Angiology. 2009 Apr-May;60(2):242-53. doi: 10.1177/0003319708318378. Epub 2008 May 27.
Tumor angiogenesis is a process where new blood vessels are formed from preexisting ones, resulting in several pathologies. Solid tumors induce angiogenesis to obtain the required nutrients and oxygen. Otherwise, tumors do not grow beyond 2 to 3 mm in diameter. Cyclooxygenase-2, an inducible enzyme important in inflammation, catalyzes the production of prostanoids from arachidonic acid. Cyclooxygenase-2 plays an important role in several cancer types, including colorectal, gastric, prostate, breast, lung, and endometrial cancer. Besides, cyclooxygenase-2 has been implicated in the progression and angiogenesis of cancers. Cyclooxygenase-2 inhibitors have been used to block angiogenesis and tumor proliferation. In this review, the recent studies related to the role of cyclooxygenase-2 in several cancer types and tumor-induced angiogenesis were compiled.
肿瘤血管生成是一个从已有的血管形成新血管的过程，会导致多种病变。实体瘤诱导血管生成以获取所需的营养和氧气。否则，肿瘤直径不会超过2至3毫米。环氧化酶-2是一种在炎症中起重要作用的诱导酶，催化花生四烯酸生成前列腺素。环氧化酶-2在多种癌症类型中发挥重要作用，包括结直肠癌、胃癌、前列腺癌、乳腺癌、肺癌和子宫内膜癌。此外，环氧化酶-2与癌症的进展和血管生成有关。环氧化酶-2抑制剂已被用于阻断血管生成和肿瘤增殖。在本综述中，汇编了与环氧化酶-2在多种癌症类型和肿瘤诱导的血管生成中的作用相关的最新研究。
