Lawenda Brian D, Kelly Kara M, Ladas Elena J, Sagar Stephen M, Vickers Andrew, Blumberg Jeffrey B
Radiation Oncology Division, Breast Health Center, Naval Medical Center San Diego, San Diego, CA, USA.
J Natl Cancer Inst. 2008 Jun 4;100(11):773-83. doi: 10.1093/jnci/djn148. Epub 2008 May 27.
Despite nearly two decades of research investigating the use of dietary antioxidant supplementation during conventional chemotherapy and radiation therapy, controversy remains about the efficacy and safety of this complementary treatment. Several randomized clinical trials have demonstrated that the concurrent administration of antioxidants with chemotherapy or radiation therapy reduces treatment-related side effects. Some data indicate that antioxidants may protect tumor cells as well as healthy cells from oxidative damage generated by radiation therapy and some chemotherapeutic agents. However, other data suggest that antioxidants can protect normal tissues from chemotherapy- or radiation-induced damage without decreasing tumor control. We review some of the data regarding the putative benefits and potential risks of antioxidant supplementation concurrent with cytotoxic therapy. On the basis of our review of the published randomized clinical trials, we conclude that the use of supplemental antioxidants during chemotherapy and radiation therapy should be discouraged because of the possibility of tumor protection and reduced survival.
尽管近二十年来一直在研究在传统化疗和放射治疗期间使用膳食抗氧化剂补充剂，但这种辅助治疗的疗效和安全性仍存在争议。几项随机临床试验表明，抗氧化剂与化疗或放射治疗同时使用可减少与治疗相关的副作用。一些数据表明，抗氧化剂可能会保护肿瘤细胞以及健康细胞免受放射治疗和某些化疗药物产生的氧化损伤。然而，其他数据表明，抗氧化剂可以保护正常组织免受化疗或放疗引起的损伤，而不会降低肿瘤控制效果。我们回顾了一些关于抗氧化剂补充剂与细胞毒性治疗同时使用的假定益处和潜在风险的数据。根据我们对已发表的随机临床试验的回顾，我们得出结论，化疗和放疗期间不应鼓励使用补充抗氧化剂，因为可能会保护肿瘤并降低生存率。
