Mirtaheri S F, Mousavi S N, Abdi Z, Hosseini E, Seyed Dorraji M S, Kabiri Esfahani F, Gholami M
Applied Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran.
Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
J Mater Sci Mater Med. 2025 Jan 13;36(1):9. doi: 10.1007/s10856-024-06857-0.
Preserving fertility is important in men under radiation therapy because healthy cells are also affected by radiation. Supplementation with antioxidants is a controversial issue in this process. Designing a biocompatible delivery system containing hydrophobic antioxidants to release control may solve these disagreements. Herein, a bifunctional periodic mesoporous organosilica (PMO) was designed to load quercetin (Quer) and its application was studied on damaged cells induced by irradiation on the male reproductive system. Quercetin-loaded on PMO significantly improved the length and width of the testis after irradiation compared to the Quer, alone (p < 0.001 and p < 0.001, respectively). Sperm viability was significantly higher in the Quer-loaded on PMO than Quer, alone after irradiation (p < 0.001). Irradiation significantly decreased the sperm count (p = 0.01), however, Quer and Quer-loaded on PMO could not increase them to the normal ranges. Quer alone and loaded on PMO significantly reduced the sperm with abnormal morphology after irradiation (p < 0.001). Quer alone, and loaded on PMO significantly increased daily production of sperm after irradiation (p < 0.001). The number of apoptotic cells significantly increased after irradiation (p < 0.001). After irradiation, Quer loaded on PMO significantly decreased the apoptotic cells compared to the irradiated (p < 0.001) and Quer, alone groups (p < 0.001). The novel synthesized PMO containing Quer reduced the side effects of irradiation on the male reproductive system.
对于接受放射治疗的男性来说，保护生育能力很重要，因为健康细胞也会受到辐射影响。在这个过程中，补充抗氧化剂是一个有争议的问题。设计一种含有疏水性抗氧化剂且能控制释放的生物相容性递送系统可能会解决这些争议。在此，设计了一种双功能周期性介孔有机硅（PMO）来负载槲皮素（Quer），并研究了其在雄性生殖系统受辐射诱导的受损细胞上的应用。与单独使用槲皮素相比，负载在PMO上的槲皮素在辐射后显著改善了睾丸的长度和宽度（分别为p < 0.001和p < 0.001）。辐射后，负载在PMO上的槲皮素组的精子活力显著高于单独使用槲皮素组（p < 0.001）。辐射显著降低了精子数量（p = 0.01），然而，单独的槲皮素和负载在PMO上的槲皮素都不能将其增加到正常范围。单独的槲皮素和负载在PMO上的槲皮素在辐射后显著减少了形态异常的精子（p < 0.001）。单独的槲皮素和负载在PMO上的槲皮素在辐射后显著增加了每日精子生成量（p < 0.001）。辐射后凋亡细胞数量显著增加（p < 0.001）。辐射后，与辐射组（p < 0.001）和单独使用槲皮素组（p < 0.001）相比，负载在PMO上的槲皮素显著减少了凋亡细胞。新合成的含有槲皮素的PMO减少了辐射对雄性生殖系统的副作用。
