Rommel B, de Villiers E M, Dürst M, Bartnitzke S, Bullerdiek J
Centre of Human Genetics and Genetic Counselling, University of Bremen, West Germany.
Cancer Genet Cytogenet. 1991 Apr;52(2):187-91. doi: 10.1016/0165-4608(91)90462-4.
Eighteen salivary gland pleomorphic adenomas, including nine with a t(3;8)(p21;q12) as the sole chromosome abnormality, were tested for the presence of human papillomavirus (HPV) DNA and for rearrangements of the cellular flanking regions of a HPV 16 integration site mapping to 3p21, as previously described in a cervical carcinoma. In none of the tumors could evidence for either HPV DNA or related sequences, or a rearranged allele of the integration site, be found.
对18例涎腺多形性腺瘤进行检测，其中9例的唯一染色体异常为t(3;8)(p21;q12)，检测其是否存在人乳头瘤病毒（HPV）DNA，以及HPV 16整合位点的细胞侧翼区域重排情况，该整合位点定位于3p21，此前在宫颈癌中已有描述。在所有肿瘤中均未发现HPV DNA或相关序列的证据，也未发现整合位点的重排等位基因。
