Semenza Gregg L
Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
IUBMB Life. 2008 Sep;60(9):591-7. doi: 10.1002/iub.93.
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF-1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF-1 activates the transcription of genes that increase O(2) availability by stimulating angiogenesis or that reprogram cellular metabolism to adapt to reduced O(2) availability. Proof of principle studies in mouse models suggests that inhibition of HIF-1 activity may have therapeutic effects, especially in combination with other anticancer drugs.
缺氧诱导因子1（HIF-1）是一种转录激活因子，介导对缺氧的适应性反应。由于基因改变和肿瘤内缺氧，HIF-1活性在大多数人类癌症中升高。HIF-1通过刺激血管生成激活增加氧气供应的基因转录，或重新编程细胞代谢以适应氧气供应减少。小鼠模型的原理验证研究表明，抑制HIF-1活性可能具有治疗作用，特别是与其他抗癌药物联合使用时。
