Chan Shih-Hsuan, Wu Chew-Wun, Li Anna F Y, Chi Chin-Wen, Lin Wen-Chang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Republic of China.
Anticancer Res. 2008 Mar-Apr;28(2A):907-11.
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that have been shown to be aberrantly expressed in many human carcinomas. Of these miRNAs, miR-21 appears to be important in tumorigenesis given its up-regulation in almost all types of human cancer examined. However, its association with the clinicopathological features of human gastric cancer has yet to be addressed.
Cancer tissues and corresponding normal tissues from 37 patients with gastric cancer were examined for the expression level of miR-21 using quantitative PCR and the clinical relevance of miR-21 was statistically analyzed.
miR-21 was overexpressed in 92% (34/37) of the gastric cancer samples examined. However, the patients with higher miR-21 expression did not have a worse prognosis.
miR-21 could serve as an efficient diagnostic marker for gastric cancer, but does not affect the clinical prognosis of gastric cancer patients.
微小RNA（miRNA）是一类内源性小非编码RNA，已证实在许多人类癌症中表达异常。在这些miRNA中，鉴于miR-21在几乎所有检测的人类癌症类型中均上调，其在肿瘤发生中似乎很重要。然而，其与人类胃癌临床病理特征的关联尚未得到探讨。
使用定量PCR检测37例胃癌患者的癌组织及相应正常组织中miR-21的表达水平，并对miR-21的临床相关性进行统计学分析。
在所检测的胃癌样本中，92%（34/37）的样本miR-21表达上调。然而，miR-21表达较高的患者预后并未更差。
miR-21可作为胃癌的有效诊断标志物，但不影响胃癌患者的临床预后。
