Takigawa Tomoko, Hibino Yuri, Kimura Shingo, Yamauchi Hiroshi, Wang Bingling, Wang Dahong, Ogino Keiki
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Hepatogastroenterology. 2008 Jan-Feb;55(81):50-3.
BACKGROUND/AIMS: To investigate the main factors correlated with the serum gamma-glutamyltransferase activity.
We measured serum gamma-glutamyltransferase activity in 248 healthy Japanese people and determined its correlations with serum antioxidants, other plasma or serum factors, urinary 8-hydroxydeoxyguanine, and lifestyle factors.
The mean serum gamma-glutamyltransferase activity was 29 IU/L. Gamma-glutamyltransferase activities of males and persons older than 45 years were significantly higher than each counterpart. Gamma-glutamyltransferase levels increased significantly with the number of cigarettes smoked per day and the frequency of alcohol consumption except for the persons who did not take alcohol. Additionally, gamma-glutamyltransferase significantly correlated with urinary 8-hydroxydeoxyguanine, and with more blood factors including serum tocopherols, carotenoids, antioxidative enzymes, lipid peroxide, and free fatty acids than urinary 8-hydroxydeoxyguanine did. In multiple regression analyses, gamma-glutamyltransferase had significant associations with retinol, 8-hydroxydeoxyguanine, docosahexaenoic acid, and cigarette smoking.
Our present findings support the hypothesis that gamma-glutamyltransferase can be used as a marker related with oxidative stress.
