衰老大鼠肾上腺交感神经对葡萄糖受体和化学感受器刺激的反射反应。

Reflex responses in adrenal sympathetic nerves to stimulation of glucoreceptors and chemoreceptors in aging rats.

作者信息

Sato A, Sato Y, Suzuki H, Trzebski A

机构信息

Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.

出版信息

J Auton Nerv Syst. 1991 Jan;32(1):63-8. doi: 10.1016/0165-1838(91)90236-v.

DOI:10.1016/0165-1838(91)90236-v

PMID:1850767

Abstract

The age-related changes in the sensitivity of reflex responses of adrenal sympathetic nerve activity following stimulation of glucoreceptors and arterial chemoreceptors were investigated in young adult rats 4-5 months old and aged rats 24-26 months old. The sensitivity of the inhibitory reflex responses to stimulation of glucoreceptors and the sensitivity of excitatory reflex responses to systemic hypoxia with end-tidal O2 concentration at 8% and 6% were well maintained in the same ranges in aged rats as in young adult rats. The sensitivity of the excitatory reflex responses to mild systemic hypoxia with end-tidal O2 concentration at 10% increased slightly but significantly in aged rats compared with that in young adult rats.

摘要

在4-5月龄的年轻成年大鼠和24-26月龄的老年大鼠中，研究了刺激糖感受器和动脉化学感受器后肾上腺交感神经活动反射反应敏感性的年龄相关变化。老年大鼠对糖感受器刺激的抑制性反射反应敏感性以及对呼气末O2浓度为8%和6%的全身性低氧的兴奋性反射反应敏感性，与年轻成年大鼠一样，在相同范围内得到良好维持。与年轻成年大鼠相比，老年大鼠对呼气末O2浓度为10%的轻度全身性低氧的兴奋性反射反应敏感性略有但显著增加。