Armentero M T, Levandis G, Bramanti P, Nappi G, Blandini F
Interdepartmental Research Center for Parkinson's Disease (CRIMP), IRCCS Neurological Institute C. Mondino, Pavia, Italy.
Exp Neurol. 2008 Aug;212(2):548-51. doi: 10.1016/j.expneurol.2008.04.006. Epub 2008 Apr 15.
Chronic reduction of the caloric intake is associated with extended lifespan, in rodents, and has been proposed to counteract neuronal loss in animal models of neurodegeneration. To test this hypothesis, we investigated the effect of dietary restriction (DR) in a rodent model of Parkinson's disease, based on the intrastriatal infusion of 6-hydroxydopamine. We could not confirm the neuroprotective effect of DR previously suggested: histological and behavioral measures indicated similar degrees of dopaminergic neuron loss in rats maintained on DR--for two or eight weeks prior to the lesion--or with free access to food.
长期减少热量摄入与啮齿动物寿命延长有关，并且有人提出这可以抵消神经退行性疾病动物模型中的神经元损失。为了验证这一假设，我们基于向纹状体内注射6-羟基多巴胺，在帕金森病啮齿动物模型中研究了饮食限制（DR）的作用。我们无法证实之前所提出的DR的神经保护作用：组织学和行为学测量表明，在损伤前接受DR处理两周或八周的大鼠，与自由进食的大鼠相比，多巴胺能神经元损失程度相似。
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