饮食限制对神经退行性疾病中神经炎症的影响。
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases.
机构信息
Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
出版信息
J Exp Med. 2021 Feb 1;218(2). doi: 10.1084/jem.20190086.
Recent and accumulating work in experimental animal models and humans shows that diet has a much more pervasive and prominent role than previously thought in modulating neuroinflammatory and neurodegenerative mechanisms leading to some of the most common chronic central nervous system (CNS) diseases. Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis, among others. This review discusses these findings and their potential application to the prevention and treatment of CNS neuroinflammatory diseases and the promotion of healthy brain aging.
最近在实验动物模型和人类中的研究工作表明，饮食在调节神经炎症和神经退行性机制方面的作用比以前认为的更为普遍和突出，这些机制会导致一些最常见的慢性中枢神经系统（CNS）疾病。慢性或间歇性的食物限制对大脑和外周代谢、免疫和肠道微生物组生物学的形成有深远的影响。卡路里摄入量、进餐频率、饮食质量和肠道微生物组之间的相互作用，调节了特定的代谢和分子途径，这些途径调节了正常大脑衰老和 CNS 神经退行性疾病期间的细胞、组织和器官的稳态以及炎症，包括阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和多发性硬化症等。这篇综述讨论了这些发现及其在预防和治疗 CNS 神经炎症性疾病以及促进健康大脑衰老方面的潜在应用。
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