Sandoval Darleen
Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA.
Physiol Behav. 2008 Aug 6;94(5):670-4. doi: 10.1016/j.physbeh.2008.04.018. Epub 2008 May 27.
Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 physiology. This review discusses the peripheral and central GLP-1 systems and presents a model whereby these systems are integrated in regulation of glucose homeostasis.
当前模型认为，外周和中枢神经系统的胰高血糖素样肽-1（GLP-1）信号传导作为不同的系统发挥作用，其中中枢神经系统的GLP-1调节食物摄入，而循环中的GLP-1调节葡萄糖稳态。越来越多的证据表明，作为中枢神经系统中调节能量稳态的一个区域，弓状核也会对激素和营养物质作出反应以调节葡萄糖稳态。最近的数据表明，GLP-1可能是作用于弓状核以调节葡萄糖稳态的另一种信号，这对传统的GLP-1生理学模型提出了挑战。本综述讨论了外周和中枢GLP-1系统，并提出了一个模型，即这些系统在调节葡萄糖稳态过程中是整合在一起的。
