小型综述：找到最佳平衡点：胰高血糖素样肽1在外周与中枢对进食及葡萄糖稳态的作用
Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis.
作者信息
Williams Diana L
机构信息
Department of Psychology, 1107 West Call Street, Florida State University, Tallahassee, Florida 32306-4301, USA.
出版信息
Endocrinology. 2009 Jul;150(7):2997-3001. doi: 10.1210/en.2009-0220. Epub 2009 Apr 23.
Abstract
Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indicates that in fact, GLP-1 in each location plays a role in these functions. This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites.
摘要
胰高血糖素样肽1（GLP-1）既是一种源自肠道的激素，也是一种在大脑中合成的神经递质。早期报告表明，GLP-1在外周发挥作用以促进胰岛素分泌并影响葡萄糖稳态，而中枢GLP-1则减少食物摄入和体重。然而，目前的研究表明，实际上，每个部位的GLP-1在这些功能中都发挥作用。这篇综述总结了外周和大脑GLP-1参与食物摄入调节和葡萄糖稳态的证据，并提出了一个GLP-1在多个部位协同作用的模型。
相似文献
1
Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis.
Endocrinology. 2009 Jul;150(7):2997-3001. doi: 10.1210/en.2009-0220. Epub 2009 Apr 23.
2
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake.
Diabetes. 2008 Aug;57(8):2046-54. doi: 10.2337/db07-1824. Epub 2008 May 16.
3
[The physiology of glucagon-like peptide-1 and its role in the pathophysiology of type 2 diabetes mellitus].
Med Clin (Barc). 2014 Sep;143 Suppl 2:2-7. doi: 10.1016/S0025-7753(14)70101-0. Epub 2014 Oct 15.
4
Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.
Diabetes. 1998 Apr;47(4):632-9. doi: 10.2337/diabetes.47.4.632.
5
Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling.
J Nutr. 2015 Apr;145(4):672-80. doi: 10.3945/jn.114.206029. Epub 2015 Feb 4.
6
Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.
Diabetes. 2000 Sep;49(9):1552-60. doi: 10.2337/diabetes.49.9.1552.
7
Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis.
Trends Endocrinol Metab. 2010 Feb;21(2):59-67. doi: 10.1016/j.tem.2009.11.007. Epub 2009 Dec 16.
8
Glucagon-related peptides and the regulation of food intake in chickens.
Anim Sci J. 2016 Sep;87(9):1090-8. doi: 10.1111/asj.12619. Epub 2016 May 6.
9
Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.
J Pharmacol Exp Ther. 2011 Jul;338(1):70-81. doi: 10.1124/jpet.111.179986. Epub 2011 Apr 6.
10
Central pre-proglucagon derived peptides: opportunities for treatment of obesity.
Curr Pharm Des. 2003;9(17):1373-82. doi: 10.2174/1381612033454775.
引用本文的文献
1
Impact of GLP-1 Receptor Agonists on Perceived Eating Behaviors in Response to Stimuli.
Diabetes Metab Syndr Obes. 2025 May 2;18:1411-1418. doi: 10.2147/DMSO.S488806. eCollection 2025.
2
Obesity: pathophysiology and therapeutic interventions.
Mol Biomed. 2025 Apr 25;6(1):25. doi: 10.1186/s43556-025-00264-9.
3
Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology.
Cells. 2025 Mar 6;14(5):387. doi: 10.3390/cells14050387.
4
Pancreatitis Risk Associated with GLP-1 Receptor Agonists, Considered as a Single Class, in a Comorbidity-Free Subgroup of Type 2 Diabetes Patients in the United States: A Propensity Score-Matched Analysis.
J Clin Med. 2025 Feb 1;14(3):944. doi: 10.3390/jcm14030944.
5
Role of FFAR3 in ketone body regulated glucagon-like peptide 1 secretion.
Biochem Biophys Rep. 2024 Jun 7;39:101749. doi: 10.1016/j.bbrep.2024.101749. eCollection 2024 Sep.
6
Pharmacological and Clinical Studies of Medicinal Plants That Inhibit Dipeptidyl Peptidase-IV.
Drug Des Devel Ther. 2023 Nov 23;17:3473-3491. doi: 10.2147/DDDT.S426870. eCollection 2023.
7
Effect of dulaglutide and long-acting insulin combination therapy in patients with type 2 diabetes: a retrospective observational study.
Diabetol Int. 2022 Jul 13;14(1):51-57. doi: 10.1007/s13340-022-00592-z. eCollection 2023 Jan.
8
The importance of estradiol for body weight regulation in women.
Front Endocrinol (Lausanne). 2022 Nov 7;13:951186. doi: 10.3389/fendo.2022.951186. eCollection 2022.
9
The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study.
Addict Biol. 2022 Sep;27(5):e13211. doi: 10.1111/adb.13211.
10
Central NPFF signalling is critical in the regulation of glucose homeostasis.
Mol Metab. 2022 Aug;62:101525. doi: 10.1016/j.molmet.2022.101525. Epub 2022 Jun 9.
本文引用的文献
1
Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling.
Endocrinology. 2009 Jun;150(6):2654-9. doi: 10.1210/en.2008-1479. Epub 2009 Mar 5.
2
Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety.
Endocrinology. 2009 Apr;150(4):1680-7. doi: 10.1210/en.2008-1045. Epub 2008 Dec 12.
3
Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway.
J Pharmacol Sci. 2008 Nov;108(3):274-9. doi: 10.1254/jphs.08090fp. Epub 2008 Nov 6.
4
Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms.
Endocrinology. 2009 Mar;150(3):1174-81. doi: 10.1210/en.2008-1221. Epub 2008 Oct 23.
5
The incretin system and its role in type 2 diabetes mellitus.
Mol Cell Endocrinol. 2009 Jan 15;297(1-2):127-36. doi: 10.1016/j.mce.2008.08.012. Epub 2008 Aug 20.
6
Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing.
Diabetes. 2008 Oct;57(10):2603-12. doi: 10.2337/db07-1788. Epub 2008 Jun 2.
7
CNS GLP-1 regulation of peripheral glucose homeostasis.
Physiol Behav. 2008 Aug 6;94(5):670-4. doi: 10.1016/j.physbeh.2008.04.018. Epub 2008 May 27.
8
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake.
Diabetes. 2008 Aug;57(8):2046-54. doi: 10.2337/db07-1824. Epub 2008 May 16.
9
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation.
Endocrinology. 2008 Aug;149(8):4059-68. doi: 10.1210/en.2007-1743. Epub 2008 Apr 17.
10
DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes.
Front Biosci. 2008 Jan 1;13:1780-94. doi: 10.2741/2799.
Zotero 插件