母鼠舔舐和梳理行为的频率与大鼠对可卡因和酒精使用的易感性呈负相关。
Frequency of maternal licking and grooming correlates negatively with vulnerability to cocaine and alcohol use in rats.
作者信息
Francis D D, Kuhar M J
机构信息
Deparment of Psychology, Berkeley, CA, USA.
出版信息
Pharmacol Biochem Behav. 2008 Sep;90(3):497-500. doi: 10.1016/j.pbb.2008.04.012. Epub 2008 Apr 26.
Abstract
Because licking and grooming behavior of dams with pups can influence some behaviors of pups when they are adults, we tested if licking and grooming scores in a maternal separation protocol correlated with cocaine or ethanol self-administration in the pups as adults. The protocol produced litters that were separated from dams for 0 (MS0), 15 (MS15) or 180 (MS180) min, and a nonhandled (NH) group as well. Self-administration of both drugs as shown in earlier studies was lowest in the MS15 group, highest in the NH group and intermediate in the other groups. Licking and grooming scores correlated negatively with drug intake and suggests that maternal care of pups can influence drug use in pups when they are adults.
摘要
由于母鼠对幼崽的舔舐和梳理行为会影响幼崽成年后的某些行为，我们测试了在母鼠分离实验中舔舐和梳理得分是否与幼崽成年后可卡因或乙醇的自我给药相关。该实验产生了与母鼠分离0分钟（MS0）、15分钟（MS15）或180分钟（MS180）的幼崽窝，以及一个未处理（NH）组。如早期研究所示，两种药物的自我给药在MS15组中最低，在NH组中最高，在其他组中处于中间水平。舔舐和梳理得分与药物摄入量呈负相关，这表明母鼠对幼崽的照顾会影响幼崽成年后的药物使用情况。
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