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一些带有4-甲硫基苄基部分的新型三唑并噻二唑的合成与抗菌活性

Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety.

作者信息

Prasad D Jagadeesh, Ashok Mithun, Karegoudar Prakash, Poojary Boja, Holla B Shivarama, Kumari Nalilu Sucheta

机构信息

Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India.

出版信息

Eur J Med Chem. 2009 Feb;44(2):551-7. doi: 10.1016/j.ejmech.2008.03.025. Epub 2008 Apr 4.

DOI:10.1016/j.ejmech.2008.03.025
PMID:18508161
Abstract

A series of substituted triazolothiadiazoles have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.

摘要

通过在三氯氧磷存在下，将4-氨基-3-[4-甲基硫代苄基]-4H-1,2,4-三唑-5-硫醇（5）与取代的芳基糠酸/芳香酸缩合，合成了一系列取代的三唑并噻二唑。三唑（5）是由4-甲基硫代苯基乙酸与硫代碳酰肼熔融得到的。通过元素分析、红外光谱、1H核磁共振和质谱研究对新合成化合物的结构进行了表征，并对其抗菌活性进行了筛选。初步结果表明，一些化合物表现出有前景的抗菌活性。

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