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What is idiosyncratic hepatotoxicity? What is it not?

作者信息

Senior John R

出版信息

Hepatology. 2008 Jun;47(6):1813-5. doi: 10.1002/hep.22332.

DOI:10.1002/hep.22332
PMID:18508312
Abstract
摘要

相似文献

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What is idiosyncratic hepatotoxicity? What is it not?什么是特异质性肝毒性？它不是什么？
Hepatology. 2008 Jun;47(6):1813-5. doi: 10.1002/hep.22332.
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Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.潜在的线粒体功能障碍在特异质性药物毒性小鼠模型中引发氟他胺诱导的氧化性肝损伤。
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Drug-related hepatotoxicity and acute liver failure.药物性肝毒性与急性肝衰竭。
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A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.一种使用每日剂量和共价结合进行特异质性药物毒性风险评估的区域分类系统。
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引用本文的文献

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Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing.肝细胞转运体在药物性肝损伤（DILI）体外检测中的作用
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2
Pharmacokinetic and toxicodynamic concepts in idiosyncratic, drug-induced liver injury.特发性、药物性肝损伤的药代动力学和毒代动力学概念。
Expert Opin Drug Metab Toxicol. 2022 Jul-Aug;18(7-8):469-481. doi: 10.1080/17425255.2022.2113379. Epub 2022 Aug 24.
3
What have we learned from animal models of idiosyncratic, drug-induced liver injury?
从药物诱导的肝损伤的动物模型中我们了解到了什么？
Expert Opin Drug Metab Toxicol. 2020 Jun;16(6):475-491. doi: 10.1080/17425255.2020.1760246. Epub 2020 May 4.
4
Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.药物性肝损伤的生物标志物：在研究、医学和监管中的进展和应用。
Expert Rev Mol Diagn. 2018 Sep;18(9):797-807. doi: 10.1080/14737159.2018.1508998. Epub 2018 Aug 13.
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"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis."自身免疫（样）"药物和草药诱导的肝损伤：分子发病机制的新见解。
Int J Mol Sci. 2017 Sep 12;18(9):1954. doi: 10.3390/ijms18091954.
6
The clinical features of drug-induced liver injury observed through liver biopsy: focus on relevancy to autoimmune hepatitis.通过肝活检观察到的药物性肝损伤的临床特征：重点关注与自身免疫性肝炎的相关性。
Clin Mol Hepatol. 2012 Jun;18(2):213-8. doi: 10.3350/cmh.2012.18.2.213. Epub 2012 Jun 26.
7
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.炎症应激与个体肝毒性：来自动物模型的提示。
Pharmacol Rev. 2009 Sep;61(3):262-82. doi: 10.1124/pr.109.001727.
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Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.美国药物性肝损伤前瞻性研究的病因、临床特征及结果
Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4. doi: 10.1053/j.gastro.2008.09.011. Epub 2008 Sep 17.
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Serum concentration-dependent hepatotoxicity in individuals receiving oral salsalate.
Dig Dis Sci. 2009 Jun;54(6):1375-6. doi: 10.1007/s10620-008-0487-4. Epub 2008 Sep 4.