Muehlschlegel Jochen D, Body Simon C
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Am J Hematol. 2008 Sep;83(9):732-7. doi: 10.1002/ajh.21205.
Variation in bleeding in the perioperative period is a complex and multifactorial event associated with immediate and delayed consequences for the patient and health care resources. Little is known about the complex genetic influences on perioperative bleeding. With the discovery of multiple variations in the human genome and ever-growing databases of well-phenotyped surgical patients, better identification of patients at risk of bleeding is becoming a reality. In this review, polymorphisms in the platelet receptor genes, plasminogen activator inhibitor, and angiotensin genes among others will be discussed. We will explore the nature, effects, and implications of the genetics that influence perioperative bleeding above and beyond surgical bleeding, particularly in cardiac surgery.
围手术期出血的变化是一个复杂的多因素事件，对患者和医疗资源会产生即时和延迟的影响。关于围手术期出血的复杂遗传影响，我们所知甚少。随着人类基因组中多种变异的发现以及具有良好表型的手术患者数据库的不断增长，更好地识别出血风险患者正成为现实。在本综述中，将讨论血小板受体基因、纤溶酶原激活物抑制剂和血管紧张素基因等的多态性。我们将探讨影响围手术期出血（尤其是心脏手术中的出血）的遗传学的性质、影响及意义，这些遗传学因素超出了手术出血的范畴。
