Zhao Xiaobin, Courtney James M
Bioengineering Unit, University of Strathclyde, Glasgow G4 0NW, United Kingdom.
J Biomed Mater Res A. 2009 Jul;90(1):282-91. doi: 10.1002/jbm.a.32020.
In this article, a novel approach for the surface modification of polymeric biomaterials by the utilization of supramolecules was studied. The supramolecules selected were cyclodextrin inclusion complexes (CICs). The biomaterial selected for surface modification was plasticized poly (vinyl chloride) (PVC-P). Results indicate that when the CICs were blended into PVC-P, they tend to migrate and "anchor" on the surface to achieve a remarkable protein-resistant surface, with improved blood compatibility. In comparison with a physical mixture of cyclodextrins and a "guest" molecule, such as poly(ethylene oxide) (PEO)-poly(propylene oxide) (PPO)-PEO and PPO-PEO-PPO for PVC-P modification, CICs modified PVC-P are more consistent in processing and achieve reproducible surface characteristics. Based on this study, a novel "anchor modification" was proposed regarding CICs modified surface. This "anchor modification" is likely to reduce plasticizer extraction from PVC-P and also can be utilized for the modification of polymers other than PVC-P.
在本文中，研究了一种利用超分子对聚合物生物材料进行表面改性的新方法。所选择的超分子为环糊精包合物（CICs）。用于表面改性的生物材料是增塑聚氯乙烯（PVC-P）。结果表明，当将CICs混入PVC-P中时，它们倾向于迁移并“锚定”在表面上，以获得具有显著抗蛋白质性能的表面，同时血液相容性得到改善。与用于PVC-P改性的环糊精和“客体”分子（如聚环氧乙烷（PEO）-聚环氧丙烷（PPO）-PEO和PPO-PEO-PPO）的物理混合物相比，CICs改性的PVC-P在加工过程中更稳定，且能实现可重复的表面特性。基于该研究，针对CICs改性表面提出了一种新型的“锚定改性”。这种“锚定改性”可能会减少PVC-P中增塑剂的析出，并且还可用于除PVC-P之外的其他聚合物的改性。
