Zhao Xiaobin, Courtney James M
Bioengineering Unit, University of Strathclyde, Glasgow G4 0NW, United Kingdom.
J Biomed Mater Res A. 2007 Mar 1;80(3):539-53. doi: 10.1002/jbm.a.30925.
A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.
研究了一种使用环糊精（CDs）来改善血液相容性的新型改性聚合物生物材料表面。选择增塑聚氯乙烯（PVC-P）进行改性，并使用聚乙烯作为参考材料。改性通过聚合物共混实现。利用纤维蛋白原和白蛋白吸附作为评估血液相容性的指标。表面表征证实CDs能够在PVC表面聚集并改变表面性质。还研究了其他亲水性聚合物如聚环氧乙烷（PEO）和PEO/聚环氧丙烷（PPO）共聚物（如普朗尼克F68（F68））与CDs的组合。这些改性材料具有显著的抗蛋白表面。特定进料比例下的β-环糊精（β-CD）/PEO和β-CD/F68组合在产生增强的血液相容性方面具有协同作用。
