Guan Xueli, Wenk Markus R
National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry, 28 Medical Drive, Number 04-26D, Singapore 117456.
Front Biosci. 2008 May 1;13:3239-51. doi: 10.2741/2923.
Nature has created an immense combinatorial and structural heterogeneity among lipids. It is becoming increasingly accepted that the vast range of unique chemical entities encodes for distinct functions within biological systems. A unique group of lipids which stands out in terms of diversity as well as biological activity are inositol-containing lipids. The most well characterized inositol lipids are the phosphoinositides, phosphorylated derivatives of glycerophosphoinositol, which play a wide variety of cellular roles in many eukaryotic cells. Less well understood are ceramides containing inositol in fungi, and inositol glycolipids in pathogens. Here we review biochemical aspects of inositol-containing lipids with a focus on novel analytical procedures for their characterization.
自然界在脂质之间创造了巨大的组合和结构异质性。越来越多的人认为，大量独特的化学实体编码了生物系统内的不同功能。在多样性和生物活性方面脱颖而出的一类独特脂质是含肌醇脂质。最具特征的含肌醇脂质是磷酸肌醇，即甘油磷酸肌醇的磷酸化衍生物，它们在许多真核细胞中发挥着多种细胞作用。人们对真菌中含肌醇的神经酰胺和病原体中的肌醇糖脂了解较少。在这里，我们综述含肌醇脂质的生化方面，重点是用于其表征的新型分析方法。
